Update on Bisphosphonates as a Treatment for Osteogenesis Imperfecta

This information update was prepared by the OI Foundation’s Medical Advisory Council.
Since the early 1990’s a class of drugs called bisphosphonates has been investigated as potential treatment for infants, children and adults with OI. Several of these drugs are approved by the U.S. Food and Drug Administration (FDA) for the treatment of adults with Paget’s disease of bone, osteoporosis, or other conditions, but not for the treatment of people with OI. Bisphosphonate therapy for OI is increasingly used worldwide, but continued close scrutiny and knowledgeable use and evaluation of these potent drugs is essential for everyone with OI……. Read more in a PDF @ OIF

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Osteogenesis imperfecta (OI) is a genetic disorder that causes a person's bones to break easily, often from little or no apparent trauma. OI is also called "brittle bone disease." OI varies in severity from person to person, ranging from a mild type to a severe type that causes death before or shortly after birth.

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